International Science Youth Forum (ISYF) 2025
Innovation Unified: Towards a Better Future
Celebrating its 17th year, the International Science Youth Forum (ISYF) continues to unite bright young minds and renowned scientists in pursuit of groundbreaking discoveries. The first ISYF held in 2009 was co-organised by Hwa Chong Institution and the Institute of Advanced Studies, NTU. This year, the 17th iteration of the International Science Youth Forum was held over the span of 5 days, from 6 to 10 January 2025, welcoming a total of 128 students and 45 educators from 15 countries. This year’s theme: “Innovation Unified: Towards A Better Future” highlighted the importance of unity in the pursuit of novel ideas and groundbreaking discoveries, to solve global challenges confronting humanity.
Students, educators, facilitators and school leaders at the ISYF 2025 Mass Photo-Taking
Over the five days, participants from around the globe immersed themselves in a variety of activities and learning experiences designed to inspire curiosity and foster collaboration. From exploring the Singapore Maritime Gallery to engaging with cutting-edge research at the NUS Electrical and Computer Engineering (ECE) labs, participants exchanged insights, sparked ideas, and built lasting friendships. Building on these immersive experiences, the forum’s masterclasses and lectures further expanded delegates’ understanding of cutting-edge science.
Professor Sow Chorng Haur giving a talk on nanoscience during the NUS tour
Students visit NUS ECE Robotics Laboratory
Masterclasses
ISYF stands out for its unique ability to connect young minds with world-renowned scientists. This year’s Masterclasses spanned disciplines such as biochemistry, theoretical physics, and more, broadening horizons and encouraging participants to delve into new and emerging fields besides their existing interests.
A notable highlight of this year's event was the participation of distinguished Nobel Laureates, such as Sir Tim Hunt, who was awarded the 2001 Nobel Prize in Physiology or Medicine for his groundbreaking discovery of regulatory protein molecules in cell division. Another major figure, Professor Takaaki Kajita, shared insights from his 2015 Nobel Prize-winning work on neutrino oscillations, a discovery that fundamentally altered our understanding of particle physics. Additionally, Professor Yael Tauman Kalai, recipient of the 2022 ACM Prize in Computing, conducted a class on Zero-Knowledge Proofs, shining light on the field of computation and cryptography.
In addition to these global luminaries, the forum also benefited from the expertise of distinguished local scientists, including Dr. Lee Hwee Kuan and Dr. Li Jingmei from A*STAR, and Professors Chan Chun Yong Eric and Ang Wee Han from NUS.
Among the eminent speakers was Associate Professor Hou Han Wei from NTU School of Mechanical & Aerospace Engineering and Lee Kong Chian School of Medicine, who expanded on recent developments in microfluidics solutions for blood fractionation, single-cell biophysical profiling, and organ-on-chip models for cardiovascular diseases.
Associate Professor Wu Wei from NTU School of Civil and Environmental Engineering shared his inspiring research on resource discovery for geothermal and water resources, highlighting the potential for developments in Singapore’s energy and water sustainability.
Students and Professor Takaaki Kajita at his masterclass
Keynote Lecture
One of the highlights of ISYF 2025 was the keynote lecture on Day 4 by Nobel Laureate Professor Hartmut Michel, who spoke on “The Challenges in Biomedicine and Agriculture.” He discussed innovative approaches to improving photosynthesis to enhance crop yields, and the limitations of rubisco, an enzyme that plays a crucial role in the dark reaction of photosynthesis, showing how research in this field could aid in resolving global hunger. In addition, through compelling case studies, Professor Michel shared recent advancements in AI-driven predictions of protein structures that may pave the way for modern drugs to treat diseases. The session concluded with a lively fireside chat and Q&A session, where delegates posed thought-provoking questions, including one on the safety of genetically modified organisms in human diets. The engaging discussions left delegates inspired and motivated to pursue impactful research, where scientific breakthroughs intersect with fields like economics, sustainability, and environmentalism.
Professor Hartmut Michel delivering the keynote lecture
(From left to right) Principal Mr Lee Peck Ping, Professor Phua Kok Khoo, Professor Lim Keng Hui and Professor Hartmut Michel at the keynote lecture
Cultural Hour
Cultural Hour on Day 3 provided a vibrant platform for students to celebrate and share their unique cultural heritages through interactive booths. Participants and facilitators had cultural exchanges, including a display of traditional attires like the Baju Cara Melayu from Brunei, the Sampot from Cambodia, the Happi coat from Japan, the baro’t saya from the Philippines, and the antique garments of Vietnam’s Nguyen Dynasty. Participants also learnt about other interesting cultural nuggets like the Korean alphabet, dim sum culture of Hong Kong, and a variety of festivals and dances.
Dressed in their traditional outfits, students shared interesting aspects of their culture
ISYF 2025 highlighted the value of diversity in fostering cross-border collaboration, a sentiment echoed throughout the forum. Speakers like Associate Professor Hou and Professor Michel emphasised the importance of interdisciplinary teamwork among engineers, biologists, and clinicians to tackle complex global issues. The call for collaboration underscored ISYF’s mission: to inspire and empower young scientists to work together toward a brighter, innovative future.
ISYF 2025 demonstrated that science stretches beyond the borders of benzene rings and mathematical equations—it is a bridge between disciplines, cultures, and generations. As the forum concluded, participants left with enriched perspectives, newfound connections, and a shared commitment to making the world a better place through science and innovation.
Written By: Yap Leia from Hwa Chong Institution
Pictures By: Wang Jixiang Jason, Poon Yee Way, Quek Zhi Xing, Chan Li Xuan Rianne from Hwa Chong Institution